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The Totteridge Institute for Advanced Studies
Publications


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NumberDescription
A01Tyrosinase autoactivation and the chemistry of ortho-quinone amines. Land EJ, Ramsden CA, Riley PA. Acc Chem Res. 2003, 36: 300-308. xxx
A02Mechanistic studies of catechol generation from secondary quinone amines relevant to indole formation and tyrosinase activation. Land EJ, Ramsden CA, Riley PA, Yoganathan G. Pigment Cell Res. 2003, 16: 397-406.
A03Rate constants for the first two chemical steps of eumelanogenesis. Land EJ, Ito S, Wakamatsu K, Riley PA. Pigment Cell Res. 2003, 16: 487-493.
A04Melanogenesis and melanoma. Riley PA. Pigment Cell Res., 2003, 16: 548-552.
A055. Formation of para-quinomethanes via 4-aminobutylcatechol oxidation and ortho-quinone tautomerism. Land EJ, Ramsden CA, Riley PA, Yoganathan G.Org. Biomed. Chem., 2003, 7; 1: 3120-3124.
A064-Cyanomethyl-ortho-quinone tautomerism and the structure of the dienophile in Gates morphine synthesis. Land EJ, Ramsden CA, Riley PA, Yoganathan G. Tetrahedron, 2003, 59: 9547-9554.
A07Melanoma and the Problem of Malignancy. Riley PA. Tohoku J.Exp. Med,. 2004, 204: 1-9.
A08Oxidation of N-substituted dopamine derivatives: irreversible formation of a spirocyclic product. E.J.Land, Almuda Perona, C.A.Ramsden, P.A.Riley. Org. Biomol. Chem., 2005, 3: 2387-2388.
A09Mechanistic studies of Melanogenesis: The Influence of N-substitution on dopamine quinone cyclization. J.Borovansky, Ruth Edge, E.J.Land, Suppiah Navaratnam, Stan Pavel, C.A.Ramsden, P.A.Riley, Nico P.M.Smit. Pigment Cell Res., 2006, 19: 170-178.
A10Dopaquinone redox exchange with dihydroxyindole and dihydroxyindole carboxylic acid. R.Edge, M.D’Ischia, E.J.Land, A.Napolitano, S.Navaratnam, L.Panzella, A.Pezzella, C.A.Ramsden, P.A.Riley. Pigment Cell Res., 2006, 19: 443-450.
A11An MO study of regioselective amine addition to ortho-quinones relevant to melanogenesis. E.J.Land, C.A.Ramsden, PA.Riley. Tetrahedron, 2006, 62: 4884-4891.
A12The Mechanism of Suicide-Inactivation of Tyrosinase: A Substrate Structure Investigation. E.J.Land, C.A.Ramsden, P.A.Riley. Tohoku J. Exp. Med., 2007, 212: 341-348.
A13Studies of para-quinone formation during tyrosinase-catalysed oxidation of 4-alkylcatechols. E.J.Land, C.A.Ramsden, P.A.Riley, M.R.L.Stratford. Arkivoc, 2008, 2008(ii): 258-267.
A14Evidence Consistent with the Requirement of Cresolase Activity for Suicide Inactivation of Tyrosinase. E.J.Land, C.A.Ramsden, P.A.Riley, M.R.L.Stratford. Tohoku J.Exp. Med., 2008, 216: 231-238.
A15Dopamine quinone chemistry: a study of the influence of amide, amidine and guanidine substituents [-NH-CX-Y] on the mode of reaction. Edward J.Land, Almudena Perona, Christopher Ramsden, Patrick Riley. Org. Biomol. Chem., 2009, 7: 944-950.
A16The influence of catechol structure on the suicide-inactivation of tyrosinase. Christopher A.Ramsden, Michael R.L.Stratford, Patrick A.Riley. Org. Biomol. Chem., 2009, 7: 3388-3390.
A17Studies of the competing rates of catechol oxidation and suicide inactivation of tyrosinase. Christopher A.Ramsden, Patrick A.Riley. Arkivoc, 2010 (x), 248-254.
A18Mechanistic studies of tyrosinase suicide inactivation. Christopher A.Ramsden, Patrick A.Riley. Arkivoc, 2010, (i), 260-274.
A19Rapid halogen substitution and dibenzodioxin formation during tyrosinase-catalysed oxidation of 4-halocatechols. MR Stratford, PA Riley, CA Ramsden. Chem.Res.Toxicol., 2011, 24, 350-356.
A20Biological Chemistry of o-Quinones. Patrick A Riley, Christopher A Ramsden, Edward J Land. In: Melanins & Melanosomes: Biosynthesis, Biogenesis, Physiological and Pathological Functions. Wiley-VCH, Weinheim. First Edition. 2011. pp. 63-86.
A21The influence of hydroquinone on tyrosinase kinetics. Michael R L Stratford, Christopher A Ramsden, Patrick A Riley. Bioorg. Med. Chem., 2012, 20, 4364-4370.
A22Mechanistic studies of the inactivation of tyrosinase by resorcinol. Michael RL Stratford, Christopher A Ramsden, Patrick A Riley. Bioorg. Med. Chem., 2013, 21, 1166-1173.
A23A Proposed Selective Mechanism based on Metal Chelation in Industrial Melanic Moths. P A Riley. Biological Journal of the Linnean Society, 2013, 109, 298-301.
A24Tyrosinase: The four oxidation states of the active site and their relevance to enzymatic activation, oxidation and inactivation. Christopher a Ramsden, Patrick A Riley. Bioorg. Med. Chem., 2014, 22, 2388-2395.
A25Mechanistic aspects of the tyrosinase oxidation of hydroquinone. Christopher A Ramsden, Patrick A Riley. Bioorg. Med. Chem. Letters, 2014, 24, 2463-2464.
A26Failure of fidelity of vertical transmission of epigenetic patterning as the basis of cancer. Patrick A Riley. Melanoma Research, 2014, 24, 424-429.
A27Haptogenic pathogenesis of vitiligo and the origin of the pattern of depigmentation. Patrick A Riley. J. Pigment. Disorders, 2014, 1, 109-203.
A28Oxidative calcium release from catechol. Patrick A Riley, Michael R L Stratford. Bioorg. & Med. Chem. Letters, 2015, 25, 1453-1454.
A29Age-specific incidence of malignancy in relation to the epigenetic model of cancer progression. Patrick A Riley. FGNAMB 2015, 1: 79-81.
A30Cancer is the outcome of defective epigenetic copying of the pattern of selective gene activity in differentiated cells. Patrick A Riley. Cancer Research Frontiers 2015, 1: 280-287.
A31The influence of pigment transfer on the risk of developing melanoma: the significance of the melanocyte ‘Amputation Cycle’. Riley PA. Journal of Analytical Oncology, 2016, 5: 87-92.
A32Investigation of the anomalous action of 5-hydroxyresorcinol on tyrosinase. Edward J Land, Christopher A Ramsden, Patrick A Riley, and Michael RL Stratford. Pigment Cell and Melanoma Research 2016, 29: 474-476.
A33The Epigenetic Theory of Carcinogenesis: p53 as The Guardian of the Epigenome. Patrick A Riley. Journal of Oncology and Cancer Research, 2017, 1: 8-13.
A34The Epigenetic Theory of Carcinogenesis: Investigation of the Model of Age-specific Incidence. Patrick A Riley PRAS Open 2017, 1: 14-19.
A35Epigenetics and Carcinogenesis: DNA Methylation Abnormalities Associated with Cancer and their Possible Source. Patrick A Riley. Biomedical Journal of Scientific and Technical Research 2018, 2: 1-3.
A36Epimutation and Cancer: Carcinogenesis Viewed as Error-Prone Inheritance of Epigenetic Information. Patrick A Riley. Journal of Oncology 2018: 1-4.
A37Epigenetic Error and Large-scale Genomic Instability in Cancer. Patrick A Riley. Biomed. J. Scientific and Technical Research 2018, 4: 1-4.
A38Radiative Heat Loss in Relation to Evolutionary Aspects of Melanin Pigmentation in Man. Patrick A Riley. Advances in Biochemistry and Biotechnology 2018; Issue 4 ABIO-173.
A39 Epigenetic Carcinogenesis and Genetic Instability: Competitive Aspects of the Malignant Phenotype. Patrick A Riley. Journal of Molecular Oncology Research 2018 Vol 2 Issue 3.
A40Cellular Proliferative Domains: Barriers to Migration. Patrick A Riley. Cancer Nature 2018; 1(1): 1-2.
A41Cancer Incidence in Relation to Species Size: The Peto Paradox in the Light of the Theory of Epigenetic Carcinogenesis. Riley PA. Journal of Medical Oncology, 2018, 1: 11-15.
A42Carcinogenesis: When transmission of epigenetic information goes awry. Research Outreach, 2018, 105: 14-17.
A43Does Iron Chelation by Melanin Explain the Ethnic Link with Covid-19 Fatality. P.A.Riley and T.G.Truscott. Biomed J Sci Tech Res., 2020, 31, 24527-25428.
A44Overcoming the problem of the lack of an immune response to cancer: A possible haptogenic approach to cancer immunotherapy. P.A.Riley. J Canc Res & Cellular Therapeutics, 2021, 5(1), 1-4.
A45Cancer: Evidence consistent with Epigenetic Carcinogenesis. Patrick A Riley. J. Cancer Res. Updates, 2022, 11; 39-42.
A46Does iron chelation by eumelanin contribute to the ethnic link with maternal mortality? R Edge, PA Riley, TG Truscott. European J Obst. & Gynae. and Reproductive Biology, 2022, 278, 107-108.
M01Melody score for 'Strolling along with Tipi' by Patrick Riley.
M01HTrombone harmony part for 'Strolling along with Tipi' by Patrick Riley.
M02Melody score, chords and lyrics for 'Arachnophobia' by Patrick Riley.
M03Melody score and chords for 'Fly Like The Phoenix' by Patrick Riley.
M03LLyrics to 'Fly Like The Phoenix'.
M04Melody score, chords and lyrics for 'Oh! For a Goat' by Patrick Riley.
M05Melody score, chords and lyrics for 'Its Far Too Late' by Patrick Riley and Tomos Kempley.
M06Melody score and chords for 'St Pancras Blues' by Mezz Mezzrow and Patrick Riley.
M07Score and lyrics for 'The Blue-footed Booby' by Patrick Riley.
M08Melody and chords for 'Brian, It's Your Birthday' by Patrick Riley.
M09Melody and lyrics for 'C'etait Un Cavalier' by Patrick Riley, Timothy Riley and Rob Bonne.
M10Melody, chords and lyrics to 'Contradiction' by Patrick Riley.
M11Melody and lyrics to the 'Eton Voting Song' by Patrick Riley.
M12Melody score for 'Little Waltz' for two trombones by Patrick Riley.
M13Melody score for 'Hey! You there!' by Patrick Riley.
M14Melody score and lyrics for 'Just Like Moses' by Patrick Riley.
M15Melody score and lyrics for 'I'm Not Quite Sure' by Patrick Riley.
M16Score of 'This Evening at a quarter to Nine' by Patrick Riley.
M17Melody score, chords and lyrics for 'Wondering Why' by Patrick Riley.
M18Melody score (in concert G) for 'Trombone Tune' by Patrick Riley.
M19Melody score of Butterfly Waltz ; a duet for trombones, by Patrick Riley 2024.
T01Perception Wave Paper 2013 draft 7
T02Old Sarum perception
T03The Grange: A brief history.
T04The Institute Crest: A note on the symbolism.
T05Outline of the hypothesis that the temperature sensitivity of sex determination in reptile embryonic development may have been the cause of the extinction of Dinosaurs over a long period of climate change.
T06A brief description of the method of leaf shape analysis with an Appendix listing the Macro program that generates the outline.
T07Anaglyph depth illusion
T08Program listings of Virtual Harmonographs and examples of each variety.
T09Epidermal melanin: sun screen or waste disposal?
T10A speculative comment about the evolution of epidermal pigmentation.
T11Outline of Magnetoception mechanism based on iron-binding to melanin in the eye - either in the retinal pigment epithelium (RPE) or in the pecten oculi.
T12The Skies Above: Exciting Planetary Events over Totteridge by Patrick Riley.
T13Outline of the epigenetic error hypothesis of carcinogenesis and the evidence consistent with the proposed mechanism.
T14Notice in UCL News of the Papillon exhibition of butterfly thermographs.